EBPRS - Derive Polygenic Risk Score Based on Emprical Bayes Theory

EB-PRS is a novel method that leverages information for effect sizes across all the markers to improve the prediction accuracy. No parameter tuning is needed in the method, and no external information is needed. This R-package provides the calculation of polygenic risk scores from the given training summary statistics and testing data. We can use EB-PRS to extract main information, estimate Empirical Bayes parameters, derive polygenic risk scores for each individual in testing data, and evaluate the PRS according to AUC and predictive r2. See Song et al. (2020) <doi:10.1371/journal.pcbi.1007565> for a detailed presentation of the method.

Last updated 4 years ago

1.30 score 2 stars 10 scripts 313 downloads

CorBin - Generate High-Dimensional Binary Data with Correlation Structures

We design algorithms with linear time complexity with respect to the dimension for three commonly studied correlation structures, including exchangeable, decaying-product and K-dependent correlation structures, and extend the algorithms to generate binary data of general non-negative correlation matrices with quadratic time complexity. Jiang, W., Song, S., Hou, L. and Zhao, H. "A set of efficient methods to generate high-dimensional binary data with specified correlation structures." The American Statistician. See <doi:10.1080/00031305.2020.1816213> for a detailed presentation of the method.

Last updated 4 years ago

1.00 score 2 scripts 228 downloads